Figure 8 | Cell Death & Differentiation

Figure 8

From: Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations

Figure 8

A model of signaling crosstalk regulating Wif1 and urs development. Evidence indicated that Wif1 is negatively regulated by Shh in the urs endoderm. The expression of Wif1 modulates the activity of Wnt-β-catenin signaling to control cell survival of the apical urs endoderm and cloaca membrane endoderm (a). A hypothetical mechanistic model to indicate how Wif1 facilitates the urs descent and cm degradation during cloaca septation (b–f)

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