Figure 2 | Cell Death & Differentiation

Figure 2

From: Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations

Figure 2

Both the LOF and GOF mutants for the β-catenin gene displayed ARM phenotypes. Ventral view of the genital tubercle region (a–g) and sagittal sections of the embryos at E18.5 (a′–g′). The β-catenin LOF embryos at E18.5 subsequent to TM administration at E9.5 (b and b′), E11.5 (c and c′) and E13.5 (d and d′). The β-catenin GOF embryos at E18.5 subsequent to TM administration at E9.5 (e and e′), E11.5 (f and f′) and E13.5 (g and g′). The red arrowheads indicate the cleft phenotype of the perineal region. gt, genital tubercle; r, rectum; t, tail; u, urethra

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