Figure 6

Critical roles of AUF1 in IL-17–enhanced therapeutic effect of MSCs on ConA-induced acute liver injury. Mice were intravenously injected with ConA (15 mg/kg); 30 min later, untreated or cytokine-pretreated wild-type or auf1^−/− MSCs were transfused. After 7.5 h, serum and livers were sampled. (a) Serum levels of ALT were measured. (b) Absolute numbers of MNCs in liver tissues were calculated (n=3–5 mice per group). Absolute numbers of CD3⁺CD4⁺ and CD3⁺CD8⁺ T cells were determined by flow cytometry. (c) Hematoxilin & eosin staining of liver sections at 8 h after ConA administration. N: necrosis area. (d) Percentages of necrosis were calculated