Figure 4 | Cell Death & Differentiation

Figure 4

From: PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Figure 4

Differential impact of loss of p53 on erythroid versus myeloid progenitors. Progenitor assays enumerating colony-forming units granulocyte-macrophage (CFU-GM) and burst-forming units-erythroid (BFU-E) for WT (n=10); NHD13 (n=10); p53−/− (n=11) and NHD13;p53−/− (n=14) mice. Each sample was processed in triplicate. Number of colonies was normalized to those seen in wild-type mice; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001

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