Figure 3
From: The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd
Suppression of c-Myc-induced B-cell lymphoma formation by Caspase-2 does not depend on Raidd. (a) Lymphoma-free survival of Eμ-Myc (n=37, mean=128 days), Eμ-Myc/Raidd−/− (n=43, mean=124 days) and Eμ-Myc/Casp-2−/− mice (n=15, mean=101 days). (b) Flow cytometric analysis of tumor immunophenotype. A comparison of the frequency of the different immunophenotype across genotypes by Chi-square test revealed differences between wt and Casp-2−/− tumors (P=0.043), whereas the overall distribution between wt and Raidd−/− tumors was not significantly different (P=0.1)
