Figure 1 | Cell Death & Differentiation

Figure 1

From: TP53: an oncogene in disguise

Figure 1

Mutation spectrum of frequently mutated genes in human cancer—Green: missense mutations; Grey: in-frame insertions and deletions; red: out-of-frame insertions/deletions and splice mutations; orange: nonsense mutations; Blue: nonsense mutations. Data were obtained from the cosmic database (http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/) except for those of the TP53 gene, obtained from http.p53.fr. BRAF: v-raf murine sarcoma viral oncogene homolog B1: KRAS, v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; IDH1, isocitrate dehydrogenase 1; IDH2, isocitrate dehydrogenase 2; PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide; TP53, tumor protein p53; BRCA1, familial breast/ovarian cancer gene 1; PTEN, phosphatase and tensin homolog gene; ARID1A, AT-rich interactive domain 1 A; RB1, retinoblastoma gene; APC, adenomatous polyposis coli gene

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