Figure 3
Most frequent protein variants in human cancer. (a) Fifteen most frequent protein mutants in the 12 types of cancer included in the Pan-Cancer study. (b) Ten most frequent protein mutants in four different types of cancer. Left y-axis: mutant variant frequency; Right y-axis: number of cancer worldwide associated with the different variants. p53 mutants are shown in red. Hotspot p53 mutants found in LUSC, such as p.R158L or p.V157F, are specific hotspot mutations associated with smoking. Frequencies for other types of cancer are shown in Supplementary Figure 1. This analysis included lung adenocarcinoma (LUAD), lung squamous carcinoma (LUSC), breast carcinoma (BRCA) and colon and rectal adenocarcinoma (COAD/READ)
