Figure 6 | Cell Death & Differentiation

Figure 6

From: Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice

Figure 6

Expression of the TACI-Ig reduces disease burden and extends the lifespan of Vav-Bcl2 mice. (a) Levels of total Ig in sera from mice of the indicated genotypes were determined at the age of 2, 8 or 12 months by ELISA. Dilutions were predetermined to produce absorbance readings in the linear range (1 : 3200). (b) Levels of anti-ds-DNA antibodies were quantified in the surviving 8- or 12-month-old mice presenting without overt signs of disease. Box blots represent values from five to nine animals per genotype. Box length equals interquartile range. Circles represent minimal and maximal ranges. Significant differences are marked with *P<0.05, **P<0.005 and are compared to the according genotype without the TACI-Ig. (c) Mice of the indicated genotypes were observed for up to 1 year. Significant differences between genotypes are marked with *P<0.05 and were analyzed using the Logrank (Mantel–Cox) test

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