Figure 6 | Cell Death & Differentiation

Figure 6

From: Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling

Figure 6

Model of expression and dependence on BCL-2 family proteins. Schematic representation of the dependence of naive B cells, GC B cells, PCs or memory B cells on pro-survival proteins BCL-2, BCL-XL or MCL-1 (black bold). Pro-apoptotic proteins that associate with indicated pro-survival proteins are show in gray. Interaction between BCL-XL and BIK in GC B cells (between brackets) seems not involved in cell survival. Arrows indicate possible routes of differentiation after activation of naive B cells

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