Figure 1

Lower TRAP1 expression is associated with more advanced disease. (a) Correlation between TRAP1 mRNA expression and tumour stage from the Tothill data set (P-values determined by the Kruskal–Wallis test). (b) Correlation between TRAP1 mRNA expression and tumour grade from the Tothill data set (P-values determined by the Wilcoxon rank sum test). (c) Kaplan–Meier estimates of the impact of TRAP1 on PFS (P-values determined by the log-rank test). (d) Total lysates obtained from PEA1-sensitive and PEA2-resistant cells were separated by SDS-PAGE and immunoblotted with the indicated antibodies. Images are representative of three independent experiments. (e) Real-time RT-PCR analysis of TRAP1 mRNAs expression in PEA1-sensitive and PEA2-resistant cells. Data are expressed as mean±S.E.M. from three independent experiments with technical triplicates each. Numbers above bars indicate the statistical significance (P-value), based on the two-tailed Student’s t-test