Figure 2
From: Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM
Modes of DREAM binding. DREAM can form two distinct contacts with DNA. It can bind to DNA via single E2F (a) or CHR (b) sites. E2F sites are contacted through E2F4-5/DP heterodimers. Distinct from this binding, contacts to CHR elements are made via the LIN54 protein. In the figure, the LIN54 component of the MuvB core complex is the only constituent that is labeled. Binding to E2F or CHR elements can be supported by CLE (c) or CDE (d) sites, respectively. CDE and CLE sites differ from E2F and CHR elements as CDE and CLE sites are unable to bind DREAM as single elements
