Table 1 Genes regulated by the p53–DREAM pathway
From: Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM
Genes regulated by the p53–DREAM pathway | ||||
|---|---|---|---|---|
Protein name | Protein | Function, enzymatic activity | GO – Gene Ontology | Gene |
Adrenocortical dyspl. pr. hom., shelterin compl. sub. telom. recruit. | ACD | Complex form., DNA binding | Telomere maintenance | ACD |
Anillin, actin-binding protein anillin | anillin | Actin binding | Mitosis | ANLN |
Rho GTPase-activating protein 11A | ARHGAP11A | GTPase activator activity | Small GTPase-mediated signal transduction | ARHGAP11A |
Rho GTPase-activating protein 11B | ARHGAP11B | Rho GTPase activation | Small GTPase-mediated signal transduction | ARHGAP11B |
Rho guanine nucleotide exchange factor 39, C9orf100 | ARHGEF39 | Rho guanyl-nucleotide exch. | Cell migration, Rho protein signal transduction | ARHGEF39 |
ADP-ribosylation factor-like protein 13B | ARL13B | GTP binding | Cilium assmb., small GTPase signal transduction | ARL13B |
ADP-ribosylation factor-like protein 6-interacting protein 1 | ARL6IP1 | Chromosomal pass. complex | Cotranslational protein targeting to membrane | ARL6IP1 |
Anti-silencing function 1B histone chaperone | ASF1B | Histone chaperone | Chromatin assembly, DNA replication | ASF1B |
Abnormal spindle-like microcephaly-associated protein | ASPM | Complex formation | Spindle assembly, mitosis, neurogenesis | ASPM, MCPH5 |
ATPase family AAA domain-containing protein 2 | ATAD2 | ATPase | Transcriptional coactivator | ATAD2 |
Aurora kinase A | AURKA | Serine/threonine kinase | Spindle/microtubule formation, mitosis | AURKA |
Aurora kinase B | AURKB | Serine/threonine kinase | Cytokinesis, histone modification, mitosis | AURKB |
BLM, Bloom syndrome RecQ like helicase | BLM | DNA helicase | DNA replication and repair | BLM |
MYB proto-oncogene like 2 | B-MYB, MYBL2 | Transcription factor | S phase, activator | MYBL2 |
Borealin, CDCA8 | Borealin, CDCA8 | Complex formation | Chromosomal passenger complex, spindle form. | CDCA8, Borealin |
BRCA1, Breast cancer type 1 susceptibility protein | BRCA1 | Ubiquitin ligase | DNA repair, transcription, ubiquitination | BRCA1, FANCS |
BRCA2, Breast cancer type 2 susceptibility protein | BRCA2 | Complex formation | DNA repair, transcription | BRCA2, FANCD1 |
BRIP1, BRCA1 interacting protein C-terminal helicase 1 | BRIP1, BACH1 | DNA helicase and ATPase | DNA replication and repair | BRIP1, FANCJ |
BUB1, mitotic checkpoint serine/threonine kinase | BUB1 | Serine/threonine kinase | Spindle formation, mitosis | BUB1 |
BUB3, mitotic checkpoint protein | BUB3 | Protein binding, WD repeats | Spindle formation, mitosis | BUB3 |
BUB1, mitotic checkpoint serine/threonine kinase B | BUBR1, BUB1B | Serine/threonine kinase | Spindle formation, mitosis | BUB1B, BUBR1 |
Calcyclin-binding protein | CACYBP | Complex formation | Ubiquitin-mediated degradation of beta-catenin | CACYBP |
Cancer susceptibility candidate 5, Kinetochore-null protein 1 | CASC5, KNL1 | Protein binding | Kinetochore, spindle formation, mitosis | KNL1, CASC5 |
Chromobox protein homolog 3, Heterochromatin prot. 1 hom. gam. | CBX3, HECH | Histone binding | Transcription, histone methyltransferase binding | CBX3 |
Coiled-coil domain-containing protein 150 | CCDC150 | CCDC150 | ||
Coiled-coil domain-containing protein 18, Sarco antig NY-SAR-24 | CCDC18 | CCDC18 | ||
Coiled-coil domain-containing protein 34, Ren carc ant NY-REN-41 | CCDC34 | CCDC34 | ||
CDC20, Cell division cycle protein 20 | CDC20, p55CDC | Complex formation | mitotic spindle assembly checkpoint, mitosis | CDC20, p55CDC |
CDC20, cell division cycle 25A, M-phase inducer phosphatase 1 | CDC25A | Tyrosine phosphatase | G1/S and G2/M transition | CDC25A |
CDC25B, Cell division cycle 25B, M-phase inducer phosphatase 2 | CDC25B | Tyrosine phosphatase | G2/M phases and abscission during cytokinesis | CDC25B |
CDC25C, cell division cycle 25C, M-phase inducer phosphatase 3 | CDC25C | Tyrosine phosphatase | G2/M phases and abscission during cytokinesis | CDC25C |
CDC6, cell division cycle 6 | CDC6 | G1/S transition, DNA replication | CDC6 | |
CDC7, cell division cycle 7 | CDC7 | Protein kinase | G1/S transition | CDC7 |
CDCA2, cell division cycle-associated protein 2, Repo-Man | CDCA2 | Complex formation | Chromosome segregation | CDCA2 |
Cell division cycle-assoc. prot. 3, trigger of mitotic entry protein 1 | CDCA3, TOME-1 | F-box-like protein | Protein ubiquitination | CDCA3, TOME-1 |
CDK1, cyclin-dependent kinase 1, cdc2 | CDK1, CDC2 | Serine/threonine kinase | G1/S and G2/M transition | CDK1, CDC2 |
CDK2, cyclin-dependent kinase 2 | CDK2 | Serine/threonine kinase | G1/S and G2/M transition | CDK2 |
CDKN2D, cyclin-dependent kinase 4 inhibitor D, p19-INK4d | CDKN2D, p19 | CDK4/6 inhibitor | G1/S transition | CDKN2D |
CDKN3, cyclin-dependent kinase inhibitor 3, CDI1, CIP2, KAP | CDKN3, CIP2 | CDK2 phosphatase | Regulation of cyclin-dependent kinase activity | CDKN3 |
Chromatin licensing and DNA replication factor 1 | CDT1 | Chromatin binding | DNA replication, mitosis | CDT1 |
CENP-A, Histone H3-like centromeric protein A | CENP-A | Chromatin binding | Nucleosome and kinetochore assembly | CENPA |
CENP-C, centromere protein C | CENP-C | Kinetochore binding | Microtubule function, cytokinesis, mitosis | CENPC |
CENP-E, centromere protein E | CENP-E | Kinetochore binding | Microtubule function, cytokinesis, mitosis | CENPE |
CENP-F, centromere protein F, Mitosin | CENP-F, Mitosin | Kinetochore binding | Microtubule function, cytokinesis, mitosis | CENPF, CENF |
CENP-L, centromere protein L | CENP-L, ICEN33 | Chromatin binding | Nucleosome and kinetochore assembly | CENPL, ICEN33 |
CENP-N, centromere protein N | CENP-N, ICEN32 | Chromatin binding | Nucleosome and kinetochore assembly | CENPN, ICEN32 |
CENP-O, centromere protein O | CENP-O | Complex formation | Nucleosome assembly, centromere, mitosis | CENPO |
CENP-W, centromere protein W | CENP-W | Complex formation | Nucleosome assembly, centromere, mitosis | CENPW |
CEP55, centrosomal protein of 55 kDa | CEP55 | Complex formation | Mitotic exit, cell separation after cytokinesis | CEP55 |
CEP152, centrosomal protein of 152 kDa | CEP152 | Protein kinase binding | Centriole and centrosome duplication | CEP152 |
CEP295, centrosomal protein 295, DD8 | CEP295, DD8 | Complex formation | centrosome, microtubules, cytoskeleton, cilium | CEP295, KIAA1731 |
CHAF1A, chromatin assembly factor 1 subunit A | CHAF1A | Histone binding | Histone octamer assembly, chromatin, replicat. | CHAF1A |
CHEK1, checkpoint kinase 1 | CHEK1 | Serine/threonine kinase | DNA damage response, G2/M transition | CHEK1 |
CHEK2, checkpoint kinase 2 | CHEK2 | Serine/threonine kinase | DNA damage response, G2/M transition | CHEK2 |
CIP2A, cancerous inhibitor of protein phosphatase 2A | CIP2A | Phosphatase inhibitor | Oncoprotein, cell adhesion, transcription | KIAA1524, CIP2A |
CIT, Citron Rho-interacting kinase | CIT, CRIK | Serine/threonine kinase | Cytokinesis, GTPase signal transduction | CIT, CRIK |
Cytoskeleton-associated protein 2, tumor- and microtub.-assoc. | CKAP2, TMAP | Microtubule stabilizing | Apoptotic process, microtubule polymerization | CKAP2 |
CKAP2L, cytoskeleton-associated protein 2-like, Radmis | CKAP2L, Radmis | Complex formation | Microtubule bundles, centrioles during mitosis | CKAP2L |
CKAP5, cytoskeleton-associated protein 5 | CKAP5 | Microtubule binding | Microtubule cytoskeleton polarity, spindle pole | CKAP5 |
Cyclin-dependent kinases regulatory subunit 1, CDC28 kin sub 1B | CKS-1, CKS-1B | Cyclin-dep. kinase binding | G1/S transition, CDK binding | CKS1B, CKS1 |
CKS-2, cyclin-dependent kinases regulatory subunit 2 | CKS-2 | Cyclin-dep. kinase binding | Meiosis I, CDK binding | CKS2 |
CMS1, ribosomal small subunit homolog | CMSS1, CMS1 | Poly(A) RNA binding | Poly(A) RNA binding | CMSS1 |
CTD small phosphatase-like protein 2 | CTDSPL2 | Protein phosphatase | BMP signaling pathway, transport from nucleus | CTDSPL2 |
Cyclin A | Cyclin A, cyclin A2 | Complex formation | Serine/threonine kinase activation, mitosis | CCNA, Ccna2 |
Cyclin B1 | cyclin B1 | Complex formation | Serine/threonine kinase activation, mitosis | CCNB1 |
Cyclin B2 | Cyclin B2 | Complex formation | Serine/threonine kinase activation, mitosis | CCNB2 |
DAP-5, Disks large-associated protein 5 | DAP-5, DLGAP5 | Metaphase/anaphase transition, ubiqutination | DLGAP5, DLG7 | |
DARS2, Aspartate-tRNA ligase, mitochondrial | DARS2 | Aspartate-tRNA ligase | Gene expression, aminoacylation for translation | DARS2 |
Protein DBF4 homolog B, activator of S phase kinase-like prot. 1 | DBF4B, ASKL1 | CDC7 kinase activation | DNA replication, G2/M transition | DBF4B, DRF1 |
DCAF16, DDB1- and CUL4-associated factor 16 | DCAF16 | Protein ubiquitination | Protein ubiquitination | DCAF16 |
DCK, deoxycytidine kinase | DCK | Nucleoside kinase | Nucleotide biosynthetic process | DCK |
DCLRE1B, 5' exonuclease Apollo | DCLRE1B, APOLLO | 5'–3' DNA exonuclease | Telomere maintenance, double-strand br. rep. | DCLRE1B |
DCP2, m7GpppN-mRNA hydrolase | DCP2 | mRNA-decapping enzyme | Regulation of mRNA stability, gene expression | DCP2 |
DNA damage-induced apoptosis suppressor, NO-inducible prot. | DDIAS, NOXIN | Apoptosis, DNA damage resp., cell cycle arrest | DDIAS, NOXIN | |
DDX10, ATP-dependent RNA helicase DDX10 | DDX10 | RNA helicase | RNA secondary structure unwinding | DDX10 |
DEK, proto-oncogene | DEK | Histone binding | Chromatin modification, mRNA processing | DEK |
DEPDC1, DEP domain-containing protein 1A | DEPDC1 | Transcriptional corepressor | GTPase activator activity, transcription | DEPDC1 |
DEPDC1B, DEP domain-containing protein 1B | DEPDC1B | GTPase activator activity | Cell migration, Wnt signaling pathway, GTPase | DEPDC1B, XTP1 |
Dihydrofolate reductase | DHFR | Oxidoreductase | DNA synthesis | DHFR |
DLEU1, Leukemia-associated protein 1 | DLEU1 | DLEU1, XTP6 | ||
DNMt3B, DNA methyltransferase 3 beta | DNMT3B | Methyltransferase | Chromatin binding, transcriptional corepressor | DNMT3B |
E2F1, E2F transcription factor 1 | E2F1 | Transcription factor | Cell cycle | E2F1 |
ECT2, epithelial cell transforming 2 | ECT2 | GTPase | Cytokinesis, spindle formation, mitosis | ECT2 |
establishment of sister chromatid cohesion N-acetyltransferase 2 | ESCO2 | Lysine N-acetyltransferase | Chromosome segregation | ESCO2 |
EXO1, Exonuclease 1 | EXO1 | DNA nuclease | DNA repair, recombination, replication | EXO1 |
EXOSC8, exosome component 8 | EXOSC8 | Exoribonuclease | RNA degradation | EXOSC8 |
EXOSC9, exosome component 9 | EXOSC9 | Complex formation | RNA degradation | EXOSC9 |
Exportin-2, CSE1 chromosome segregation 1-like | Exportin-2 | Export receptor importin-a | Protein transport from/to nucleus | CSE1L |
Histone-lysine N-methyltransferase, enhancer of zeste 2 polycomb | EZH2 | Lysine N-methyltransferase | Histone modification, chromatin organization | EZH2 |
FAM64A, family with sequence similarity 64 member A | FAM64A | Complex formation | Mitosis | FAM64A |
FAM83D, family with sequence similarity 83 member D | FAM83D | Complex formation | Mitosis | FAM83D |
FANCA, Fanconi anemia complementation group A | FANCA | Complex formation | Fanconi anemia, DNA repair | FANCA |
FANCB, Fanconi anemia complementation group B | FANCB | Complex formation | Fanconi anemia, DNA repair | FANCB |
FANCC, Fanconi anemia complementation group C | FANCC | Complex formation | Fanconi anemia, DNA repair | FANCC |
FANCD2, Fanconi anemia complementation group D2 | FANCD2 | Complex formation | Fanconi anemia, DNA repair | FANCD2 |
FANCE, Fanconi anemia complementation group E | FANCE | Complex formation | Fanconi anemia, DNA repair | FANCE |
FANCG, Fanconi anemia complementation group G | FANCG | Complex formation | Fanconi anemia, DNA repair | FANCG |
FANCI, Fanconi anemia complementation group I | FANCI | DNA binding, complex form. | Fanconi anemia, DNA repair | FANCI |
FANCL, Fanconi anemia complementation group L | FANCL | Ubiquitin ligase | Fanconi anemia, DNA repair | FANCL |
FANCM, Fanconi anemia complementation group M | FANCM | ATPase, DNA binding | Fanconi anemia, ubiquitination, DNA repair | FANCM |
FBXO5, F-box protein 5, Early mitotic inhibitor 1, EMI1, FBX5 | FBXO5 | Complex formation | Mitosis | FBXO5 |
FEN1, flap structure-specific endonuclease 1 | FEN1 | DNA nuclease | DNA repair | FEN1, RAD2 |
FOXM1, forkhead box M1 | FOXM1 | Transcription factor | G2 phase, mitosis, activator | FOXM1 |
FZR1, fizzy/cell division cycle 20 related 1 | FZR1 | Activator of ubiquitination | Mitosis, anaphase promoting complex/cyclos. | FZR1 |
G2E3, G2/M-phase specific E3 ubiquitin protein ligaseprovided | G2E3 | Ubiquitin ligase | G2 phase, mitosis | G2E3 |
GASL2L3, growth arrest specific 2 like 3 | GAS2L3 | Complex formation | Cytokinesis | GAS2L3 |
GPSM2, G-protein signaling modulator 2provided | GPSM2 | GDP-dissociation inhibitor | G-protein coupled receptor sign., mitotic spindle | GPSM2 |
GTSE1, G2 and S-phase expressed 1 | GTSE1 | Complex formation | Microtubule organization | GTSE1 |
histone, H2A histone family member X | H2AFX, H2AX | Histone | Nucleosome formation, DNA repair | H2AFX |
histone, H2A histone family member Z | H2AFZ, H2AZ | Histone | Nucleosome formation, embryonic development | H2AFZ |
haspin, germ cell associated 2 | haspin, GSG2 | Serine/threonine kinase | Mitosis, microtubule organization | GSG2 |
HAUS augmin like complex subunit 6 | HAUS6 | Complex formation | Cytokinesis, spindle assembly | HAUS6 |
HAUS augmin like complex subunit 8 | HAUS8, HICE1 | Complex formation | Cytokinesis, spindle assembly | HAUS8 |
histone cluster 1 H2A family member e | HIST1H2AE, H2A.1 | Histone | Nucleosome formation | HIST1H2AE |
histone cluster 1 H2A family member m | HIST1H2AM | Histone | Nucleosome formation | HIST1H2AM |
histone cluster 1 H2B family member f | HIST1H2BF | Histone | Nucleosome formation | HIST1H2BF |
histone cluster 1 H2B family member h | HIST1H2BH | Histone | Nucleosome formation | HIST1H2BH |
histone cluster 1 H2B family member i | HIST1H2BI | Histone | Nucleosome formation | HIST1H2BI |
histone cluster 1 H2B family member m | HIST1H2BM | Histone | Nucleosome formation | HIST1H2BM |
histone cluster 1 H3 family member c | HIST1H3C | Histone | Nucleosome formation | HIST1H3C |
histone cluster 1 H3 family member d | HIST1H3D | Histone | Nucleosome formation | HIST1H3D |
histone cluster 1 H4 family member c | HIST1H4C | Histone | Nucleosome formation | HIST1H4C |
histone cluster 2 H2A family member b | HIST2H2AB | Histone | Nucleosome formation | HIST2H2AB |
histone cluster 2 H2A family member c | HIST2H2AC | Histone | Nucleosome formation | HIST2H2AC |
Holliday junction recognition protein | HJURP | DNA binding, chaperone | Centromere, nucleosome assembly | HJURP |
HMGB2, High mobility group protein B2 | HMGB2, HMG2 | DNA binding | Chromatin, transcription, recombination | HMGB2 |
HMMR, Receptor for hyaluronan-med. motility, RHAMM, CD168 | HMMR, RHAMM | Complex formation | Cell adhesion, mitosis, hyaluronic acid binding | HMMR, RHAMM |
HNRNPA0, heterogeneous nuclear ribonucleoprotein A0 | HNRNPA0 | RNA binding | mRNA processing | HNRNPA0 |
HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1 | hnRNP A2/B1 | RNA binding | RNA and single-stranded telomeric DNA binding | HNRNPA2B1 |
BORA, Aurora kinase A activator, protein aurora borealis | HsBora | Kinase binding | Spindle/microtubule formation, mitosis | BORA |
IFT80, intraflagellar transport 80 | IFT80 | Complex formation | Cilia assembly | IFT80 |
INCENP, inner centromere protein | INCENP | Complex formation | Cytokinesis, centromere, microtubule binding | INCENP |
ING1, inhibitor of growth family member 1 | ING1 | Complex formation | p53 interaction, tumor suppr., chromatin | ING1 |
Ki-67 | Ki-67 | Complex formation | Mitotic chromosome stabilization | MKI67 |
KIF11, kinesin family member 11 | KIF11, EG5 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF11, EG5 |
KIF14, kinesin family member 14 | KIF14 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF14 |
KIF15, kinesin family member 15 | KIF15 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF15 |
KIF18A, kinesin family member 18A | KIF18A | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF18A |
KIF20B, kinesin family member 20B, M-phase phosphoprotein-1 | KIF20B, MPP1 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF20B, MPP1 |
KIF22, kinesin family member 22 | KIF22, KID | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF22, KID |
KIF23, kinesin family member 23, Mitotic kinesin-like protein 1 | KIF23, MKLP1 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF23, MKLP1 |
KIF24, kinesin family member 24 | KIF24 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF24 |
KIF2C, kinesin family member 2C, Mitotic centromere-ass. kinesin | KIF2C, MCAK | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF2C |
KIF4A, kinesin family member 4A | KIF4A, KIF4 | Microtubule binding | Microtubule function, cytokinesis, mitosis | KIF4A |
KIFC1, kinesin family member C1 | KIFC1 | ATPase | Microtubule motor activity, spindle assembly | KIFC1 |
KPNA2, Importin subunit alpha-1, karyopherin subunit alpha 2 | KPNA2 | Protein transporter | Nuclear protein import, recombination | KPNA2 |
KPNB1, Importin subunit beta-1, karyopherin subunit beta 2 | KPNB1 | Protein transporter | Nuclear protein import | KPNB1 |
lamin B1 | lamin B1 | Lamin | Nuclear lamina | LMNB1 |
Acidic leucine-rich nuclear phosphoprotein 32 family member E | LANP-like protein | Histone chaperone | Histone exchange, chromatin modification | ANP32E |
LIN-54 DREAM MuvB core complex component | LIN54 | DNA binding | Transcription, activator, repessor, cell cycle | LIN54 |
LIN-9 DREAM MuvB core complex component | LIN9 | complex, transcription | transcription, activator, repessor, cell cycle | LIN9 |
LSM5, U6 snRNA-associated Sm-like protein LSm5 | LSM5 | RNA binding | mRNA processing | LSM5 |
MAD2, Mitotic spindle assembly checkpoint protein MAD2A | MAD2 | Complex formation | Mitotic spindle assembly checkpoint, mitosis | MAD2L1, MAD2 |
MAD3, Max dimerization protein 3 | MAD3, MXD3 | Transcription factor | MYC/MAX-related, repressor | MXD3 |
GREATWALL, microtubule associated serine/threonine kinase like | MASTL | Serine/threonine kinase | G2 phase, mitosis | MASTL |
MCM2, minichromosome maintenance complex component 2 | MCM2 | Complex formation, ATPase | DNA helicase, replication | MCM2 |
MCM3, minichromosome maintenance complex component 3, HCC5 | MCM3, HCC5 | Complex formation, ATPase | DNA helicase, replication | MCM3 |
MCM4, minichromosome maintenance complex component 4 | MCM4 | Complex formation, ATPase | DNA helicase, replication | MCM4 |
MCM5, minichromosome maintenance complex comp. 5, CDC46 | MCM5, CDC46 | Complex formation, ATPase | DNA helicase, replication | MCM5 |
MCM6, minichromosome maintenance complex component 6, Mis5 | MCM6, Mis5 | Complex formation, ATPase | DNA helicase, replication | MCM6 |
MCM7, minichromosome maintenance complex comp. 7, CDC47 | MCM7, CDC47 | Complex formation, ATPase | DNA helicase, replication | MCM7 |
MCM8, minichromosome mainten. 8 homolog. recomb. repair factor | MCM8 | Complex formation, ATPase | Helicase, replication, homolog. recomb. repair | MCM8 |
MDC1, mediator of DNA damage checkpoint 1 | MDC1 | Complex formation | DNA repair, checkpoint control, S, G2, M phase | MDC1 |
MELK1, maternal embryonic leucine zipper kinase | MELK | Serine/threonine kinase | Apoptosis, G2/M transition | MELK |
METTL4, methyltransferase like 4 | METTL4 | DNA Methyltransferase | DNA methylation, adenine-specific | METTL4 |
MIS18, kinetochore protein A | MIS18A | Complex formation | Centromere complexes, chromosome segregat. | MIS18A |
MIS18BP1, MIS18 binding protein 1 | MIS18BP1 | Complex formation | Centromere complexes, chromosome segregat. | MIS18BP1 |
MND1, meiotic nuclear divisions 1 | MND1 | DNA binding | Meiosis, DNA recombination | MND1 |
MSH2, mutS homolog 2, Heredit. non-polyp. color. Canc. 1, HNPCC | MSH2 | Complex formation, ATPase | DNA repair, mismatch repair | MSH2, HNPCC |
MSH6, mutS homolog 6 | MSH6 | Complex formation, ATPase | DNA repair, mismatch repair | MSH6 |
metal response element bind. transcription fact. 2, polycomblike 2 | MTF2, PCL2 | DNA binding | Histone binding, transcription, repression | MTF2 |
MZT1, Mitotic-spindle organizing protein 1 | MZT1, MOZART1 | Complex formation | Tubulin binding, centrosome, spindle assembly | MZT1 |
NASP, nuclear autoantigenic sperm protein | NASP | Histone binding | DNA replication | NASP |
NCAPD2, condensin, non-SMC condensin I complex subunit D2 | NCAPD2 | Complex formation | Chromosome condensation, mitosis | NCAPD2 |
NCAPD3, condensin, non-SMC condensin II complex subunit D3 | NCAPD3 | Complex formation | Chromosome condensation, mitosis | NCAPD3 |
NCAPG, condensin, non-SMC condensin I complex subunit G | NCAPG | Complex formation | Chromosome condensation, mitosis | NCAPG |
NCAPG2, condensin, non-SMC condensin II complex subunit G2 | NCAPG2 | Complex formation | Chromosome condensation, mitosis | NCAPG2 |
NCAPH, condensin, non-SMC condensin I complex subunit H | NCAPH | Complex formation | Chromosome condensation, mitosis | NCAPH |
NDC1, transmembrane nucleoporin | NDC1, TMEM48 | Complex formation | Nuclear envelope assembly, nuclear transport | NDC1, TMEM48 |
NDC80, kinetochore complex component NDC80 | NDC80 | Complex formation | Chromosome segregation, microtubule binding | NDC80 |
NEIL3, nei like DNA glycosylase 3 | NEIL3 | DNA endonuclease | DNA repair | NEIL3 |
NEK2, NIMA related kinase 2 | NEK2 | Serine/threonine kinase | Chromosome condensation, spindle assembly | NEK2 |
NET1, neuroepithelial cell transforming 1 | NET1 | Rho guanyl-nucleotide exch. | Apoptosis, signal transduction | NET1 |
NOP58, ribonucleoprotein | NOP58 | Complex formation | Ribosome biogenesis | NOP58 |
NOXIN, DNA damage-induced apoptosis suppressor | NOXIN, DDIAS | Apoptosis, response to DNA damage, mitosis | C11orf82, DDIAS | |
nuclear casein kinase and cyclin-dependent kinase substrate 1 | NUCKS1, JC7 | DNA binding | DNA damage response, homologous recomb. | NUCKS1 |
NUF2, NDC80 kinetochore complex component | NUF2, CDCA1 | Complex formation | Chromosome segregation, microtubule binding | NUF2 |
NUP107, nucleoporin 107 | NUP107 | Complex formation | Nucleocytoplasmic transport | NUP107 |
NUP205, nucleoporin 205 | NUP205 | Complex formation | Nucleocytoplasmic transport | NUP205 |
NUP35, nucleoporin 35 | NUP35, NUP53 | Complex formation | Nucleocytoplasmic transport | NUP35 |
NUP85, nucleoporin 85, Pericentrin-1 | NUP85 | Complex formation | Nucleocytoplasmic transport | NUP85 |
NUSAP1, nucleolar and spindle associated protein 1 | NUSAP1, SAPL | Complex formation | Mitotic spindle microtubules | NUSAP1 |
OCT1, POU class 2 homeobox 1, Octamer-binding protein 1 | OCT1, POU2F1 | Transcription factor | Proliferation, immune modulation | POU2F1 |
OIP5, Opa interacting protein 5 | OIP5 | Complex formation | Centromere binding, chromosome segregation | OIP5 |
ORC1, origin recognition complex subunit 1 | ORC1 | DNA binding | DNA replication | ORC1 |
PALB2, partner and localizer of BRCA2 | PALB2, FANCN | Complex form., DNA bindg. | Fanconi anemia, DNA repair, replication | PALB2, FANCN |
CENP-M, Centromere protein M | PANE1, CENP-M | Complex formation | Kinetochore formation, mitosis | CENPM |
PARPBP, PARP1 binding protein | PARPBP | Complex formation | DNA repair, genomic stability | PARPBP |
pericentrin | Pericentrin | Complex formation | Centrosome, microtubules, cilia assembly | PCNT |
PHF19, PHD finger protein 19 | PHF19 | Complex formation | Histone binding, transcription, repression | PHF19 |
PICH, Plk1-interacting checkpoint helicase | PICH, ERCC6L | DNA helicase | DNA repair, spindle assembly, anaphase | ERCC6L |
PIF1, 5'-to-3' DNA helicase | PIF1 | ATPase, DNA helicase | DNA repair, telomere maintenance | PIF1 |
PLK1, Polo-like kinase 1 | PLK1 | Serine/threonine kinase | G2/M transition, mitosis | PLK1 |
PLK4, Polo-like kinase 4 | PLK4 | Serine/threonine kinase | G2/M transition, mitosis | PLK4, SAK |
POC5, centriolar protein | POC5 | Centriole elongation | POC5 | |
POLA1, DNA polymerase alpha-1, catalytic subunit | POLA1 | DNA polymerase | DNA replication | POLA1 |
POLD1, DNA polymerase delta 1, catalytic subunit | POLD1 | DNA polymerase, exonucl. | DNA replication, DNA repair | POLD1 |
POLD3, DNA polymerase delta 3, accessory subunit | POLD3 | DNA polymerase, exonucl. | DNA replication, DNA repair, mismatch repair | POLD3 |
POLE, DNA polymerase epsilon, catalytic subunit | POLE | DNA polymerase | DNA replication, DNA repair | POLE |
POLQ, DNA polymerase theta | POLQ | DNA polymerase | DNA replication, DNA repair | POLQ |
POP7 homolog, ribonuclease P/MRP subunit | POP7 | Ribonuclease | tRNA processing | POP7 |
PPIH, peptidylprolyl isomerase H | PPIH | Peptidylprolyl isomerase | Protein folding, mRNA splicing | PPIH |
PRC1, protein regulator of cytokinesis 1 | PRC1 | Complex formation | Cytokinesis, spindle formation, mitosis | PRC1 |
PRIM1, primase (DNA) subunit 1 | PRIM1 | DNA primase, RNA synthesis | DNA replication | PRIM1 |
PRIM2, primase (DNA) subunit 2 | PRIM2 | DNA primase | DNA replication, telomere maintenance | PRIM2 |
PRR11, proline rich 11 | PRR11 | Cell cycle regulation | PRR11 | |
Partner of SLD Five 1, DNA replication complex GINS protein PSF1 | PSF1, GINS1 | DNA helicase | DNA helicase, replication | GINS1 |
Partner of SLD Five 2, DNA replication complex GINS protein PSF2 | PSF2, GINS2 | Complex formation | DNA helicase, replication | GINS2 |
PSRC1, proline and serine rich coiled-coil 1 | PSRC1, DDA3 | Complex formation | Microtubule polymerization, mitosis | PSRC1 |
Securin, PTTG1, pituitary tumor-transforming 1 | PTTG1, securin | Complex formation | Mitotic spindle assembly checkpoint, mitosis | PTTG1 |
RACGAP1, Rac GTPase-activating protein 1 | RACGAP1 | Regulation of small GTPase | Cytokinesis, mitosis | RACGAP1 |
RAD18, E3 ubiquitin protein ligase | RAD18 | Ubiquitin ligase | Detection of DNA damage, DNA repair | RAD18 |
RAD21, cohesin complex component | RAD21 | Complex formation | Chromosome cohesion, DNA repair, apoptosis | RAD21 |
RAD51, recombinase | RAD51, FANCR | DNA-dependent ATPase | Fanconi anemia, DNA repair | RAD51, FANCR |
RAD54-like | RAD54L | DNA helicase | DNA repair, mitotic recombination | RAD54L |
RANGAP1, Ran GTPase-activating protein 1 | RANGAP1 | Ran GTPase activator activity | Nuclear pore complex, kinetochore, mitosis | RANGAP1 |
RECQL4, RecQ like helicase 4 | RECQL4 | DNA helicase, ATPase | DNA repair, replication, recombination | RECQL4 |
REEP4, receptor accessory protein 4 | REEP4 | Complex formation | Microtubule bdg, nuclear envelope reassembly | REEP4 |
RHINO, RAD9-HUS1-RAD1 interacting nuclear orphan 1 | RHINO | Complex formation | DNA repair, cellular response to DNA damage | RHNO1, C12orf32 |
RIF1, replication timing regulatory factor 1 | RIF1 | Complex formation | DNA repair, checkpoint control, telemore bindg. | RIF1 |
RNASEH2A, ribonuclease H2 subunit A | RNASEH2A | RNA endonuclease | DNA replication | RNASEH2A |
RNF26, ring finger protein 26 | RNF26 | Ubiquitin ligase | Endosomal maturation and trafficking | RNF26 |
RPA2, replication protein A2 | RPA2 | Complex form., DNA bindg. | DNA repair, replication | RPA2 |
RTKN2, rhotekin 2 | RTKN2 | Rho GTPase effector | Cell cycle regulation, apoptosis | RTKN2 |
SAS-6 centriolar assembly protein, Spindle assem. abn. protein 6 | SAS6, SASS6 | Complex formation | Centrosome duplication, procentriole formation | SASS6 |
SCLT1, sodium channel and clathrin linker 1 | SCLT1 | Complex formation | Clathrin binding, cilia assembly | SCLT1 |
Separase, extra spindle pole bodies like 1 | Separase, ESPL1 | Protease | Chromosome segregation | ESPL1 |
SETD8, lysine methyltransferase 5A | SETD8, KMT5A | Lysine N-methyltransferase | Protein methylation, transcriptional repression | KMT5A, SETD8 |
SGO1, shugoshin 1 | SGO1, SGOL1 | Complex formation | Chromosome segregation, centromere binding | SGOL1, SGO1 |
SGO2, shugoshin 2 | SGO2, SGOL2 | Complex formation | Sister chromatid cohesion, meiosis, centromere | SGOL2, SGO2 |
SHCBP1, SHC binding and spindle associated 1 | SHCBP1 | Cell proliferation | SHCBP1 | |
SKA1, Spindle and kinetochore-associated protein 1 | SKA1 | Complex formation | Kinetochore, microtubules, mitosis | SKA1 |
SKAP, kinetochore localized astrin/SPAG5 binding protein | SKAP, KNSTRN | Complex formation | Mitotic spindle, chromosome segregation | KNSTRN |
SKP2, S-phase kinase associated protein 2 | SKP2 | F-box-like protein | Protein ubiquitination | SKP2 |
SLC25A40, solute carrier family 25 member 40 | SLC25A40 | Mitochondrial carrier | SLC25A40 | |
SMC-2, structural maintenance of chromosomes 2 | SMC-2 | ATP binding | DNA condensation, mitosis | SMC2 |
SMC-4, structural maintenance of chromosomes 4 | SMC-4 | ATP binding | DNA condensation, mitosis | SMC4 |
structural maintenance of chromos. Flex. hinge domain contain. 1 | SMCHD1 | Complex formation | DNA methylation | SMCHD1 |
Sororin, CDCA5 | Sororin, CDCA5 | Chromatin binding | Mitotic sister chromatid cohesion | CDCA5, Sororin |
Sp4, transcription factor | SP4 | Transcription factor | Transcription | SP4 |
SPAG5, sperm associated antigen 5 | SPAG5 | Complex formation | Mitotic spindle, chromosome segregation | SPAG5 |
SPC25, NDC80 kinetochore complex component | SPC25 | Complex formation | Chromosome segregation, microtubule binding | SPC25 |
Spindly, Coiled-coil domain-containing protein 99 | SPDL1/CCDC99 | Kinetochore binding | Establishment of mitotic spindle orientation | SPDL1/CCDC99 |
STIL, SCL/TAL1 interrupting locus | STIL | Embryonic development, cell proliferation | STIL | |
STK17B, serine/threonine kinase 17b (apoptosis-inducing) | STK17B, DRAK2 | Serine/threonine kinase | Apoptosis | STK17B, DRAK2 |
Survivin, baculoviral IAP repeat containing 5 | Survivin, BIRC5 | Chromosomal pass. complex | Mitosis, cytokinesis, transcription | BIRC5 |
SUZ12, polycomb repressive complex 2 subunit | SUZ12 | Complex formation | Transcriptional repession, histone methylation | SUZ12 |
TACC3, transforming acidic coiled-coil containing protein 3 | TACC3, ERIC1 | Complex formation | Spindle/microtubule formation, mitosis | TACC3 |
Tastin, Trophinin-assisting protein, TROAP | Tastin, TROAP | Complex formation | Cell adhesion | Tastin, TROAP |
TCERG1, transcription elongation regulator 1 | TCERG1, CA150 | Transcription factor | Inhibition of transcript elongation | TCERG1 |
TIMELESS, timeless circadian clock | TIMELESS, TIM1 | Complex formation | Circadian rhythm, DNA repair, replication | TIMELESS |
Thymidine kinase 1 | TK1 | Kinase | DNA synthesis | TK1 |
Thymopoietin, Lamina-associated polypeptide 2, isoform alpha | TMPO, LAP2 | Complex formation | Nuclear structure, post-mitotic nuclear assembly | TMPO, LAP2 |
TOP2A, topoisomerase (DNA) II alpha | TOP2A | DNA topoisomerase | Mitosis, meiosis, chromosome segregation | TOP2A |
TPX2, microtubule nucleation factor | TPX2 | Complex formation | Mitotic spindle assembly, apoptosis, G2/M trans | TPX2 |
TRAIP, TRAF interacting protein, TRIP | TRAIP, TRIP | Ubiquitin ligase | Signal transduction, apoptosis, spindle, mitosis | TRAIP, TRIP |
Treslin, TOPBP1 interacting checkpoint and replication regulator | Treslin, SLD3 | Complex formation | DNA replication, DNA repair, checkpoint control | TICRR, Treslin |
TTK, Mitotic checkpoint kinase Mps1, TTK protein kinase | TTK, MPS1 | Serine/threonine/tyr. kinase | Spindle formation, mitosis | TTK, MPS1 |
SNRPA, small nuclear ribonucleoprotein polypeptide A | U1A, SNRPA | Complex formation | U1 snRNA binding, splicing | SNRPA, U1A |
UACA, Uveal autoantigen with coiled-coil domains and ankyrin repeats | UACA | Complex formation | Apoptosis | UACA |
UBE2C, Ubiquitin-conjugating enzyme E2 C, UbcH10 | UBE2C, UbcH10 | Ubiquitin conjug. enzyme | Mitosis | UBE2C, UbcH10 |
UBE2S, Ubiquitin-conjugating enzyme E2 S | UBE2S | Ubiquitin conjug. enzyme | Exit from mitosis | UBE2S |
UBE2T, Ubiquitin-conjugating enzyme E2 T | UBE2T, FANCT | Ubiquitin conjug. enzyme | Fanconi anemia, DNA repair, ubiquitination | UBE2T, FANCT |
UDG, uracil DNA glycosylase | UDG, UNG | Uracil DNA N-glycosylase | DNA repair, base-excision repair | UNG |
USP1, ubiquitin specific peptidase 1 | USP1, UBP | Endopeptidase | De-ubiquitination, neg. regulation DNA repair | USP1 |
Wee1-like protein kinase | WEE1 | Serine/threonine kinase | G2/M transition, mitosis | WEE1 |
WD repeat containing antisense to TP53, Telomerase Cajal body pr. | WRAP53, TCAB1 | Telomerase component | Telomere maintenance, p53 antisense transcript | WRAP53 |
YEATS4, YEATS domain-containing 4 | YEATS4, GAS41 | Complex formation | Transcription, histone acetylation | YEATS4, GAS41 |
ZNF367, zinc-finger protein 367, CDC14B | ZNF367 | DNA binding | Transcription | ZNF367 |
ZRANB3, zinc-finger, RAN-binding domain-containing 3 | ZRANB3, AH2 | Helicase and endonuclease | DNA repair, cellular response to DNA damage | ZRANB3, AH2 |
