Table 2 DREAM targets among Fanconi anemia, dyskeratosis congenita, and related DNA repair and telomere maintenance genes
From: Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM
Gene name | Fanconi | DREAM pathway | Repressed by p53 |
|---|---|---|---|
Complementation | Target | ||
Group or DC | Fischer et al. 17 | Jaber et al. 101 | |
BLM | ✓ | ✓ | |
BRCA1 | FANCS | ✓ | ✓ |
BRCA2 | FANCD1 | ✓ | ✓ |
BRIP1 (BACH1) | FANCJ | ✓ | ✓ |
DCLRE1B (Apollo) | ✓ | ||
DEK | ✓ | ✓ | |
DKC1 (Dyskerin) | Dyskeratosis Congen. | unclear | |
ERCC4 (XPF, RAD1) | FANCQ | no | |
FANCA | FANCA | ✓ | ✓ |
FANCB | FANCB | ✓ | ✓ |
FANCC | FANCC | ✓ | |
FANCD2 | FANCD2 | ✓ | ✓ |
FANCE | FANCE | ✓ | |
FANCF | FANCF | no | |
FANCG | FANCG | ✓ | |
FANCI | FANCI | ✓ | ✓ |
FANCL | FANCL | ✓ | |
FANCM | FANCM | ✓ | ✓ |
FEN1 | ✓ | ✓ | |
GAR1 | unclear | ✓ | |
PALB2 | FANCN | ✓ | ✓ |
RAD51 | FANCR | ✓ | ✓ |
RAD51C | FANCO | unclear | ✓ |
RECQL4 | ✓ | ✓ | |
RTEL1 | Dyskeratosis Congen. | unclear | |
SLX4 (BTBD12) | FANCP | no | |
Timeless | ✓ | ✓ | |
TINF2 (TIN2) | Dyskeratosis Congen. | no | |
UBE2T | FANCT | ✓ | ✓ |
ACD | ✓ | ||
RIF1 | ✓ | ||
PIF1 (RRM3) | ✓ | ||
RPA2 | ✓ | ||
TRAIP | ✓ | ||
WRAP53 (TCAB1) | ✓ |
