Figure 2 | Cell Death & Differentiation

Figure 2

From: MOMP, cell suicide as a BCL-2 family business

Figure 2

Overview of MOMP and its exceptional nuances. In general, apoptotic stress results in complete MOMP and apoptotic cell death. Scenarios of partial MOMP: iMOMP, in which case cells might survive if caspase activity is inhibited and minority MOMP, when only a small portion of mitochondria undergo MOMP. The latter version of partial MOMP results in cell survival, but caspase-dependent signaling pathways can be activated and DNA damage might occur, which might lead to malignant transformation of cells

Back to article page