Table 1 List of proteins that partner with mutant p53 proteins to enable GOF

From: Mutant p53 partners in crime

Missense mutant

Species

Disease

Cell line

Sp1

Ets1/Ets2

YAP1

NF-Y

CBP

NF-kB

VDR

SREBP

E2F1

p63/p73

Smad2/Smad3

Mre11

Nrf2

STAT3

Ref

C194D

H

Breast cancer

T47D

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

H179Y R282W

H

Keratinocytes

HACAT

-

-

-

-

-

-

-

-

-

+/ND

+/ND

-

-

-

25

H193L

H

Head and neck cancer

CAL27

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

M237I

H

Breast cancer

SUM149PT

-

-

-

-

-

-

-

-

-

-

-

-

+

-

32

R110P E258V R175H R282W

H

Osteosarcoma

SaOS-2

-

-

-

-

-

-

-

-

-

+/+

-

-

-

-

14

R175H R273H R248Q R248W

H

Embryonic kidney

HEK293T

-

ND/+

-

-

-

-

-

-

-

-

-

-

-

-

35

R175H

H

Breast cancer

SKBr3

-

-

-

-

-

-

+

-

-

-

-

-

-

-

31

R175H

H

Breast cancer

SKBr3

-

-

-

+

-

-

-

-

-

-

-

-

-

-

16

R175H

H

Lung cancer

H1299

-

-

-

-

-

-

-

-

+

-

-

-

-

-

37

R175H

H

Lung cancer

H1299

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R175H

H

Breast cancer

SKBr3

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R175H

M

Fibroblasts

MEFs

-

-

-

-

-

-

-

-

-

+/ND

+/+

-

-

-

25

R175H

H

Breast cancer

HCC1395

-

-

-

-

-

-

-

-

-

-

-

-

+

-

32

R175H

M

Pancreatic cancer

KPflC

-

-

-

-

-

-

-

-

-

-/+

-

-

-

-

15

R175H R273H R248W R282W-

H

Lung cancer

H1299

-

-

-

-

-

-

-

-

-

-

+/+++

-

-

-

26

R248L

H

Head and neck cancer

FaDu

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R248W

H

LFS

MDAH087

-

+/+++

-

-

-

-

+

-

-

-

-

-

-

-

27

R248W

H

Pancreatic cancer

MIA PaCa-2

-

+/+++

-

-

-

-

+

-

-

-

-

-

-

-

27

R248W

H

Colon cancer

Colo320

-

-

-

-

-

-

-

-

-

-

-

+

-

-

33

R248W

H

Pancreatic cancer

MIA PaCa-2

+

-

-

-

-

-

-

-

-

-

-

-

-

-

22

R249S

H

Breast cancer

BT-549

-

-

-

+

-

-

-

-

-

-

-

-

+

-

32

R273H

H

Breast cancer

MDA-MB-468

-

ND/+

-

-

-

-

-

-

-

-

-

-

-

-

35

R273H

H

Breast cancer

MDA-MB-468

-

-

-

-

-

-

-

+

-

-

-

-

-

-

5

R273H

H

Glioblastoma

U373

-

-

-

+

+

-

-

-

-

-

-

-

-

-

24

R273H

H

Glioblastoma

SNB19

-

-

-

+

+

-

-

-

-

-

-

-

-

-

24

R273H

H

Colon cancer

HT-29

-

-

-

+

-

-

-

-

-

-

-

-

-

-

16

R273H

H

Lung cancer

H1299

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R273H

H

Pancreatic cancer

PANC-1

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R273H

H

Breast cancer

MDA-MB-468

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R273H

H

Colon cancer

SW620

-

-

-

-

-

-

-

-

-

-

-

+

-

-

33

R273H

H

Colon cancer

SW480

-

-

-

-

-

-

-

-

-

-

-

+

-

-

33

R273H

H

Breast cancer

MDA-MB-468

-

-

-

-

-

-

-

-

-

-

-

-

+

+

32

R273H

M

Pancreatic cancer

KPflC

-

-

-

-

-

-

-

-

-

-/++

-

-

-

-

15

R273H, P309S

H

Colon cancer

SW480

-

-

-

+

-

-

-

-

-

-

-

-

-

-

16

R273H, P309S

H

Colon cancer

SW-480

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R280K

H

Breast cancer

MDA-MD-231

-

-

+

-

-

-

-

-

-

-

-

-

-

-

30

R280K

H

Breast cancer

MDA-MD-231

-

-

-

-

-

-

-

-

-

+/ND

+/ND

-

-

-

25

R280K

H

Breast cancer

MDA-MD-231

+

-

-

-

-

-

-

-

-

-

-

-

-

-

22

R280K

H

Breast cancer

MDA-MD-231

-

-

-

+

-

-

-

-

-

-

-

-

+

+

32

  1. All protein interactions were determined through co-immunoprecipitation assays in listed cell lines. H, human. M, mouse. ND, no data available. (-) not examined
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