Figure 1 | Cell Death & Differentiation

Figure 1

From: Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma

Figure 1

MiR-3188 is overexpressed in HCC tissues and plasma, and the expression is associated with the prognosis of HCC patients. (a) qRT-PCR analysis of the expression levels of miR-3188 in plasma between 10 pairs of HCC patients and healthy volunteers. The miR-3188 expression levels in healthy volunteer plasma were significantly lower than those in HCC patients’ plasma (5.23±1.45 versus 127.9±18.92, n=10, P<0.01). (b) qRT-PCR analysis of the expression levels of miR-3188 in 150 pairs of HCC patients’ tumor tissues and corresponding adjacent liver tissues. The expression of miR-3188 in tumor tissues was significantly higher than that in adjacent liver tissues. After curative liver resection, the cumulative disease-free survival (c) and overall survival (d) rates in patients with high miR-3188 expression were significantly lower than those with low miR-3188 expression. **P<0.01

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