Figure 7
From: Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy
Electron microscopy of HL60 cells treated with apigenin for different time points. (a) Control cells, without treatment (original magnification, × 3000). (b) Cells treated with apigenin for 8 h, showing classical apoptotic cells (condensed chromatin, reduction of cell size, and no vacuoles); cells with dense mitochondria and no condensed chromatin and cells with size reduction, many vacuoles and no condensed chromatin (original magnification, × 3000). (c) HL60 cell treated for 24 h (original magnification, × 3000), showing necrotic cells and cells with many vacuoles. (d) Cells treated for 24 h with apigenin, showing cells with dense chromatin, many vacuoles and double membrane, detail in high magnification (original magnification, × 20 000) of vacuoles with cytosol content
