Figure 4 | Cell Death & Disease

Figure 4

From: Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors

Figure 4

Galantamine-mediated neuroprotection is not due to decreased intraocular pressure. (a) Daily i.p. administration of galantamine did not reduce intraocular pressure (IOP) over a period of several weeks. (b) Fluorogold-labeled RGCs in a flat mount preparation from intact, uninjured Sprague–Dawley rat retina. (c) Galantamine treatment led to marked survival of axotomized RGCs with respect to PBS-treated eyes (d). (e) Quantitative analysis of RGC survival after intraocular injection of galantamine (solid bars) or PBS (hatched bars) (n=5–6 rats per group) (ANOVA, ***P<0.001). The density of RGCs in intact, uninjured Sprague–Dawley rat retinas is shown as reference (open bar). Data are expressed as the mean±S.E.M. Scale bars (a–c): 100 μm

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