Figure 2 | Cell Death & Disease

Figure 2

From: Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1

Figure 2

The modeled structure of mutated CADM1. (a) The Ig3 domain of CADM1, which was built using the Ig3 domain of NCAM as a template and registered in MODBASE.39 The NH2- and COOH-terminal strands of the model are red and yellow, respectively. The residues shown as sticks are possibly involved in the trans-interaction. The mutant residues, H246 and Y251, are in cyan. (b) The superimposed models of wild-type (black), H246N mutant (green), and Y251S mutant (blue) CADM1 using MOLMOL.40 The amino acid sequence, PQVHIQMTYP, shows the altered region in the Y251S mutant compared with the wild-type

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