Figure 3 | Cell Death & Disease

Figure 3

From: Resistance to caspase-8 and -9 fragments in a malignant pleural mesothelioma cell line with acquired cisplatin-resistance

Figure 3

Expression of inhibitor of apoptosis proteins and HtrA2 in in vitro acquired cisplatin-resistance. (a) P31 and P31res1.2 content of c-IAP1, c-IAP2, survivin, XIAP and HtrA2 determined with a Proteome profiler array for human apoptosis-related proteins. Data presented as means±S.E.M. of duplicate analysis. (b) Detection of the caspase-3 and -9 inhibitor XIAP and of the XIAP inhibitor HtrA2XIAP in malignant pleural mesothelioma cells (P31) and a sub-line with in vitro acquired cisplatin-resistance (P31res1.2), determined in absence and presence of equitoxic and equiapoptotic concentrations of cisplatin, after exposure times as indicated. Actin was used as protein loading control. Image representative of three separate experiments

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