Figure 2 | Cell Death & Disease

Figure 2

From: Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

Figure 2

Region-specific acute neuroprotection in p53-deficient mice after status epilepticus. (a–h) Representative photomicrographs showing FJB staining of degenerating neurons in various ipsilateral fields and corresponding graphs quantifying counts for wild-type (wt) and p53-deficient (p53−/−) mice 72 h after status epilepticus. Note the significantly reduced neuronal death in p53−/− mice in (a and b) CA3 and (g and h) neocortex. Lens in a, x40; lens in c, e, g, x20. Scale bar in a, 75 μm; c (for c, e, g) 150 μm. Data are from n=10–20 per group. *P<0.05 compared to wt. ns, non-significant

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