Figure 3

Increased electrographic seizures after KA in p53-deficient mice. (a) Graph showing sum of high amplitude and high frequency seizure time during status epilepticus in wild-type (wt) and p53-deficient (p53−/−) mice (n=8–12 per group). *P<0.05 compared with wild-type. (b) Representative traces of electrographic seizures recorded after KA using surface electrodes in mice of each genotype. Note the extended polyspiking in p53−/− mice