Figure 5 | Cell Death & Disease

Figure 5

From: Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Figure 5

Autophagy is a cytoprotective mechanism in ESOM-treated melanoma cells. (a) Me30966 cells pretreated with Baf-A1 (40 nM) show increased sensitivity to ESOM-induced apoptosis in association with a further increased LC3-II accumulation. (b) Knockdown of Atg5 and beclin-1 induces a cytosolic localization of LC3 as compared with autophagosomal localization in control Me30966 cells. (c and d) Knockdown of Atg5 and beclin-1 increases the cytotoxicity of ESOM in Me30966 cells and WM793 cells, respectively

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