Figure 6 | Cell Death & Disease

Figure 6

From: Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Figure 6

Schematic model of ESOM cytotoxic effects on melanoma cells. The picture shows the possible cellular pathways through which ESOM induces cell death in melanoma cells. Inhibition of proton extrusion is a crucial step in the antitumour activity of ESOM, as this effect causes acidification of the cytosol and alkalinization of lysosomes. The severe disturbance of cellular pH gradients and the accumulation of ROS, likely through the contribution of both NADPH oxidase and mitochondrial dysfunction, induce the activation of caspases and the alteration of autophagic flux, thus leading and contributing to cell death

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