Figure 5
From: Enhanced cartilage regeneration in MIA/CD-RAP deficient mice
(a) No regulation of p54nrb through ERK signaling. Inhibition of ERK signaling using MEK1/2 specific inhibitors UO126 and PD98059 in WT mMSC led to no regulation of p54nrb expression, neither on mRNA nor on protein level. The data are represented as means±S.D., after normalization to DMSO-treated cells. (b and c) Schematic drawing of MIA/CD-RAP regulation in cartilage development. MIA/CD-RAP mediates differentiation of mesenchymal stem cells through regulation of collagen type II expression through activation of p54nrb, arrows represent activation. Bold arrows indicate differentiation progress. (ns, not significant)
