Figure 1

Representative images of different grades of necrosis. (a) Absence of necrosis ( × 200). (b) Mild necrosis: few foci of polymorphonuclear cells (arrows) can be observed through the lobule surrounding few necrotic hepatocytes ( × 200). (c) Moderate necrosis: some foci of polymorphonuclear cells can be observed around the section of the centrolobular vein (CLV) associated to some necrotic hepatocytes ( × 200). (d) Severe necrosis: large necro-inflammatory area with bridging between two centrolobular veins (CLV; × 200)