Table 4 Clinical data during liver transplantation in patients receiving a IP and non-IP allograft

From: Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes

 

Non-steatotic allografts

Steatosic allografts

    

Variable

IP ( n =14) group I

Non-IP ( n =14) group II

IP ( n =12) group III

Non-IP ( n =10) group IV

P- value I versus II a

P- value III versus IV a

P- value I versus III a

P- value II versus IV a

Hepatic function

 AST at day 5 (IU/l)

42±33

79±57

55±40

139±164

0.047

0.10

0.37

0.22

 ALT at day 5 (IU/l)

82±39

247±194

222±246

423±409

0.005

0.17

0.046

0.17

 AST peak (IU/l)

235±189

458±308

881±1323

862±762

0.029

0.96

0.08

0.09

 ALT peak (IU/l)

187±94

577±361

795±796

728±724

0.0006

0.84

0.009

0.51

 PT (%) at day 5

61±13

67±10

63±20

68±9

0.18

0.48

0.73

0.74

 Bilirubin at day 7 (μmol/l)

46±44

38±21

106±148

78±45

0.55

0.57

0.16

0.007

Hospitalization

 Intensive care unit stay (days)

12±7

11±6

15±10

12±5

0.67

0.42

0.47

0.59

 Total stay in hospital (days)

28±8

29±13

52±43

33±9

0.70

0.18

0.049

0.53

 Retransplantation

1/14

1/14

0/12

0/10

—

—

0.52

0.52

Rejection

 Acute rejection

2/14

5/14

2/12

6/10

0.15

0.048

0.40

0.17

 Rejection activity index (mean±S.D.)

5±1.4

5.2±1.3

5±1.7

4.7±0.9

0.86

0.73

1.00

0.66

 Acute rejection delay (median in month)

0.5

1.25

0.5

2

0.84

0.92

0.99

0.99

 Chronic rejection

0/14

2/14

2/12

7/10

0.24

0.017

0.20

0.009

 Ductopenia (mean±S.D. in %)

—

44.5±15.6

49.7±23.1

36.5±10.2

—

0.15

—

0.22

 Chronic rejection delay (median in month)

—

42

9

36

—

0.09

—

1.00

 Follow-up (mean±S.D. in months)

53±18

60±30

47±27

64±26

0.44

0.16

0.51

0.76

  1. aMeans were compared using the Student's t-test
  2. Dichotomous variables were compared using the Fisher exact test
  3. Medians were compared with Kolmogorov–Smirnov test
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