Table 5 Histological and immunohistochemical and analysis on post-reperfusion livers

From: Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes

 

Non-steatotic allografts

Steatosic allografts

    

Variable

IP ( n =14) group I a

Non-IP ( n =14) group II

IP ( n =12) group III

Non-IP ( n =10) group IV

P- value I versus II b

P- value III versus IV b

P- value I versus III b

P- value II versus IV b

Surgical necrosis (presence)

9/14

9/14

8/12

10/10

0.30

0.067

0.32

0.047

 Absent

5/14

5/14

4/12

0/10

0.30

0.067

0.32

0.047

 Mild

7/14

7/14

5/12

7/10

0.29

0.15

0.28

0.21

 Moderate

1/14

1/14

2/12

3/10

0.52

0.30

0.36

0.16

 Severe

1/14

1/14

1/12

0/10

0.52

0.54

0.52

0.58

Necrotic index

0.71±0.67

0.67±0.61

0.80±0.71

0.97±0.32

0.85

0.50

0.75

0.17

Activated caspase 3

0/12

0/14

1/12

3/10

—

0.20

0.50

0.059

Beclin 1

2/12

0/14

9/12

2/10

0.20

0.015

0.006

0.16

LC3

2/12

2/14

9/12

3/10

0.40

0.046

0.006

0.26

Beclin 1+ LC3

1/12

0/14

7/12

2/10

0.46

0.071

0.014

0.16

  1. aIn all, 12 paraffin blocks were available for group I to allow further immunohistochemical analysis
  2. bMeans were compared using the Student's t-test
  3. Dichotomous variables were compared using the Fisher's exact test
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