Figure 7

Effects of combination of AdsTRAIL and newer anticancer agents on human organotypic glioma slices. Glioma slice cultures were established from freshly resected residual glioblastoma tissue derived from three patients and treated with AdsTRAIL alone (100 MOI) or in combination with temozolomide (20 μM), vorinostat (5 μM), and MG132 (10 μM) for 24 h and harvested as single-cell suspensions, which were further analyzed by flow cytometry to identify the apoptosis sub-G1 fraction