Figure 5 | Cell Death & Disease

Figure 5

From: TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

Figure 5

Summary of the RNAi study of TNF-induced necroptosis in L929 cells. At TNFR1 complex II, the apoptotic proteins FADD, caspase-8 and c-FLIP suppress TNF-induced necroptosis. RIP1 knockdown shifts TNF-induced TRADD-independent necroptosis to TRADD-dependent apoptosis. The combined knockdown of RIP1 and caspase-8 blocks apoptosis but does not affect the extent of cell death. This RIP1-independent necroptotic cell death can be blocked by deleting RIP3 as well.

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