Table 2 p53 status of UKF-NB-3 and UKF-NB-6 sublines adapted to nutlin-3 in independent experiments

UKF-NB-3^rNutlin^10 μM

G245C^a,b

UKF-NB-6^rNutlin^10 μM

K132N^c, P223L^b

UKF-NB-3^rNutlin^10 μM I

Wild type

UKF-NB-6^rNutlin^10 μM I

S241F^b

UKF-NB-3^rNutlin^10 μM II

Wild type

UKF-NB-6^rNutlin^10 μM II

C277F^b

UKF-NB-3^rNutlin^10 μM III

Wild type

UKF-NB-6^rNutlin^10 μM III

C277F^b

UKF-NB-3^rNutlin^10 μM IV

Wild type

UKF-NB-6^rNutlin^10 μM IV

C135F^c, D281Y^c

UKF-NB-3^rNutlin^10 μM V

Wild type

UKF-NB-6^rNutlin^10 μM V

C277F^b

UKF-NB-3^rNutlin^10 μM VI

P278A^c

UKF-NB-6^rNutlin^10 μM VI

R248Q^c

UKF-NB-3^rNutlin^10 μM VII

D281G^c

UKF-NB-6^rNutlin^10 μM VII

C277F^b

UKF-NB-3^rNutlin^10 μM VIII

D281G^c

UKF-NB-6^rNutlin^10 μM VIII

C277F^b

UKF-NB-3^rNutlin^10 μM IX

D281G^c

UKF-NB-6^rNutlin^10 μM IX

C277F^b

UKF-NB-6^rNutlin^10 μM X

R248Q^b