Table 3 p53 status in nutlin-3-adapted sublines of the p53 wild-type UKF-NB-3 clone 2

From: Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells

Subline

p53 status

UKF-NB-3clone2rNutlin10 μMI

Wild type

UKF-NB-3clone2rNutlin10 μMII

Wild type

UKF-NB-3clone2rNutlin10 μMIII

H168R (heterozygote)

UKF-NB-3clone2rNutlin10 μMIV

H168R (heterozygote)

UKF-NB-3clone2rNutlin10 μMV

C277F (heterozygote)

UKF-NB-3clone2rNutlin10 μMVI

H168R (heterozygote), G245S (homozygote)

UKF-NB-3clone2rNutlin10 μMVII

F270L (heterozygote)

UKF-NB-3clone2rNutlin10 μMVIII

H168R (heterozygote)

UKF-NB-3clone2rNutlin10 μMIX

R280S (heterozygote), D281G (heterozygote)

UKF-NB-3clone2rNutlin10 μMX

N239D (heterozygote)