Figure 2 | Cell Death & Disease

Figure 2

From: Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair

Figure 2

Comparison of cell sensitivity with chemotherapeutic agents between UDG+/+ and UDG−/− cells. The cytotoxicity induced by different chemotherapeutic agents was analyzed by clonogenic formation assay in UDG-proficient or -deficient cells (a) pemetrexed treatment (0–400 nM); (b) 5-FU treatment (0–20 μM); (c) temozolomide treatment (0–1500 μM; P-value=0.687); and (d) cisplatin treatment (0–40 μM, P-value=0.753). Results are representative of three independent experiments

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