Figure 3 | Cell Death & Disease

Figure 3

From: Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair

Figure 3

Cellular response to uracil-DNA induced by pemetrexed. Comparison of cell cycle progression before and after treatment with pemetrexed between (a) UDG−/− and (b) UDG+/+ cells. Protein alterations in the response to DNA damage, cell cycle progression, and cell death were detected in (c) UDG−/− cells and (d) UDG+/+ cells treated with pemetrexed. Cells were collected at 6 and 24 h after pemetrexed treatment. Results are representative of two independent experiments

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