Figure 6 | Cell Death & Disease

Figure 6

From: Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair

Figure 6

The potentiation of pemetrexed cytotoxicity by MX. (a and b) Cytotoxicity of pemetrexed alone and in combination with MX was examined by a clonogenic survival assay in UDG+/+ and UDG−/− cells. (c) MX potentiated the cytotoxicity of pemetrexed in H460 cells. (d) Comparison of UDG protein levels between H460 and A549 by western blotting assay. (e) Comparison of sensitivity to pemetrexed between H460 and A549 cells. Results are representative of three independent experiments

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