Figure 5

Inhibitors of mitochondrial respiratory chain and proteasomal degradation enhanced expression of HMGR. (a) HMGR expression and ERK phosphorylation were evaluated in total-protein-lysates (30 μg) of LNCaP cultured 6 h in the presence or absence of rotenone (400 nM), antimycin A (160 ng/ml) and oligomycin (8 μg/ml). (b) HMGR in total-protein lysates of LNCaP cultured 6 h in the absence (control) or presence of ALLN at the indicated dosages