Figure 8
From: Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer
The effect of lovastatin and mevalonate on tumor formations of LNCaP in athymic nude mice. Athymic BALB/c (nu/nu) mice were subcutaneously inoculated with LNCaP. The effect of lovastatin and mevalonate on tumor growth was investigated as described in Materials and Methods. The tumor volumes were measured weekly and calculated. The relative tumor volume was calculated as percent of control±S.D. by assuming the rate of each tumor volume on day 0 to be 100% (n=6). Student's t-test compared the control and lovastatin group showed significance at day 14, 21 and 28 days (*P<0.01), and the control and mevalonate groups at day 14 and 21 (**P<0.01) and 28 days (***P<0.02)
