Figure 2

Downregulation of GABAAR subunit expressions in the cortical neurons after traumatic brain injury. (a) Immunohistochemical staining of the GABAAR-α1 subunit (green) and Nissl staining (magenta) in the contralesional cortex of the injured mice at 2 weeks after the injury. GABAAR-α1-positive signals decreased in all the layers in injured group. Scale bar: 50 μm. (b and c) Quantification of GABAAR-α1-positive signals by immunohistochemical staining at 2 (b) and 4 weeks (c) after the injury. The data represent the mean±S.D. (n=3, each group); *P<0.05, **P<0.01 versus the sham mice (Mann–Whitney U-test)