Figure 5 | Cell Death & Disease

Figure 5

From: Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling

Figure 5

Sprouting of CST fibers is inhibited by muscimol infusion in the contralesional cortex after brain injury. (a and b) Photographs of the recrossing CST fibers labeled with BDA at the C7 level in the saline-treated (a) or muscimol-treated (b) mice (Z stack, each 0.5 μm, by confocal laser-scanning microscopy). The recrossing CST fibers were marked with arrowheads. Scale bar: 50 μm. (c and d) Quantification of the number of recrossing CST fibers (c) and their positive areas in the denervated cervical spinal cord (d) at each cervical level in the saline-treated (gray bars) and muscimol-treated (black bars) mice at 4 weeks after the injury. Muscimol infusion decreased the number of sprouting axons into the denervated side. The data represent the mean±S.D. (n=5, each group); *P<0.05, **P<0.01 versus the saline-treated mice (Mann–Whitney U-test)

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