Figure 7
From: Cell-type-specific regulation of raft-associated Akt signaling
Akt signaling in lipid rafts of U87MG and N2a cells treated with chemotherapeutics and NMDA with and without aPPD. Total Akt and Akt phosphorylation in the lipid rafts were inhibited by aPPD in U87MG cells treated with TAXOL or Vinblastine (a and c). Phosphorylation of BAD in the lipid rafts was also reduced by aPPD (b and d). aPPD restored phosphorylation of Akt and BAD in the lipid rafts of N2a cells treated with NMDA (e and f). *P<0.05, **P<0.001 compared with the control, t-test (n=3 independent experiments)
