Figure 2 | Cell Death & Disease

Figure 2

From: Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state

Figure 2

ISM induces EC apoptosis through αvβ5 integrin. (a) Knockdown of β5, but not β3 integrin, suppressed ISM-induced apoptosis. (b) Knockdown of β5 integrin rescued ISM-suppressed proliferation. (c) More free αvβ5 integrins are available in ECs growing on FN-coated surface. VN, vitronectin; ISM, isthmin; FN, fibronectin. (d) ISM induces more extensive apoptosis in ECs grown on FN-coated surface

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