Figure 7 | Cell Death & Disease

Figure 7

From: Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state

Figure 7

Identification of the αvβ5 integrin-binding site in ISM. (a) Schematic diagrams showing the truncated ISM protein fragments produced as recombinant proteins in E. coli. Numbers refer to the amino acid position in the full-length secreted ISM protein. The positon of KD316AA mutation is indicated by the arrowhead. The black triangle at the right end of each truncated protein represent His-tag. (b) EC adhesion to various ISM protein fragments compared with 0.2% gelatin. 3% BSA was used as the negative control. (c) KD316AA mutation abolished the anti-tube formation activity of ISM

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