Figure 8 | Cell Death & Disease

Figure 8

From: Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state

Figure 8

Schematic illustration of the dual functions of ISM. (a) Immobilized ISM serves as integrin agonist to mediate cell survival/migration by activating FAK. (b) Soluble ISM induces cell apoptosis through IMD (direct activation of caspase-8). ‘?’ indicates the unresolved question if additional molecules are involved in the integrin–caspase-8 complex formation

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