Figure 2
From: Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis
Evidence of canalicular membrane rupture in NCFR cells. (a) A hepatocyte pre-labeled by RITC-dextran (indicated by asterisk (*)) developed ballooning and rupturing of an overlying bile canaliculus. Red arrows indicate ballooning canaliculus, green arrows indicate bile canaliculi and blue arrows indicate blebs, which might be dislodged into sinusoids. (b) Another example more clearly shows progressive ballooning change of 2 bile canaliculi (arrows) that blew up later. Scale bars indicate 40 μm in a and 20 μm in b
