Figure 6
From: Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis
Schematic illustrations showing our hypothesis on the sequential morphological changes of APAP-induced hepatocyte injury. Normal hepatocytes became injured as manifested by loss of R6G labeling or uptake of either dextran or Sytox through On rupture of apical membrane, bile containing CF gushed from bile canaliculi into the damaged cells. Later on, bile persistently leaked into the cells as manifested by retaining CF. We proposed that rupture of canalicular membrane is a critical determinant of point of no return in the course of hepatocyte necrosis
