Figure 5
From: CYLD regulates keratinocyte differentiation and skin cancer progression in humans
Hematoxilin/eosin staining of A-control, A-CYLDWT and CYLDC/S tumors. (a–c) A-control tumors are solid undifferentiated SCCs. (d–f) A-CYLDWT tumors contain large cavities as a result of tumor degeneration (arrow in d) (g–i); often they also form cystic, differentiated structures. (j–k) A-CYLDC/S SCCs are spindle-shape tumors. Compare the cords of fibroblasts-like cells forming the mutant tumors with the keratinocytes of the A-control SCCs (c). Tumors (10–12) of each type were analyzed
