Figure 6 | Cell Death & Disease

Figure 6

From: Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

Figure 6

Metformin potentiated the effect of mTOR inhibitor to induce lymphoma cell autophagy. (a) In Daudi and Jurkat cells, metformin enhanced the growth-inhibitory effect of the mTOR inhibitor temsirolimus. (b) Metformin combined with temsirolimus induced less lymphoma cell growth inhibition in the AMPK siRNA group than in the Con siRNA group, *P<0.001 comparing with the Con siRNA group. (c) Co-treatment resulted in LC3-II upregulation. (d) Lymphoma cell growth inhibition was overcome by autophagy inhibitor 3-methyladenine. (e) Combined oral metformin with temsirolimus significantly inhibited xenograft lymphoma growth, comparing with the control group or each agent alone. (f) The metformin/temsirolimus combination frequently induced lymphoma cell autophagy

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