Figure 1
Impaired reproductive performance of NHERF1-mutant female mice. (a) Cumulative frequency of first pregnancy in NHERF1(+/+) (n=15), (+/−) (n=29) and (−/−) (n=11) females. Gray-shaded area indicates peak ages of frequency accumulation. (b) The ability of the dams from a to nurse their litter is represented as the distribution litter sizes per mother’s genotype. (c) Newborn count per mother’s genotype. (d) Pup weight per mother’s genotype. The lower limit for the normal weight was arbitrarily defined as (mean−1.5 S.D.) of weaning body weights from five NHERF1(+/+) litters (day 21, n=42 pups). For (a–d), †P<0.05, ‡P<0.01, versus (+/+)
