Table 1 Characterization of mesenchymal subtype-like U87-2M1 glioma cells by DNA microarray analysis

From: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme

Gene ontology term

Enrichment score

Count

%

P -value

FDR

(a) Enriched gene clusters in U87-2M1 glioma cells a

 GO:0007155

     

Cell adhesion

7.16

72

7.64

5.27E−08

9.52E−05

 GO:0048731

     

System development

5.33

182

19.3

8.15E−09

1.47E−05

 GO:0001944

     

Vasculature development

5.12

37

3.92

7.75E−08

1.40E−04

 GO:0043062

     

Extracellular structure organization

3.89

30

3.18

1.11E−08

2.01E−05

 GO:0042060

     

Wound healing

3.46

27

2.86

9.07E−06

1.64E−02

 GO:0048513

     

Organ development

3.32

132

14.0

8.21E−06

1.48E−02

(b) Enriched gene clusters in U87-2M1 glioma cells after miR-10b silencing b

 GO:0019222

     

Regulation of metabolic process

6.93

401

24.4

1.36E−11

2.53E−08

 GO:0042127

     

Regulation of cell proliferation

5.26

111

6.74

2.99E−08

5.53E−05

 GO:0048522

     

Positive regulation of cellular process

5.05

221

13.4

6.95E−09

1.29E−05

 GO:0032502

     

Developmental process

4.52

333

20.2

3.42E−07

6.34E−04

 GO:0000280

     

Nuclear division

3.86

39

2.37

1.19E−05

2.21E−02

 GO:0051270

     

Regulation of cell motion

3.67

35

2.13

2.22E−05

4.10E−02

 GO:0001944

     

Vasculature development

3.61

43

2.61

9.54E−06

1.77E−02

 GO:0043067

     

Regulation of programmed cell death

3.56

105

6.38

4.85E−06

8.99E−03

  1. Abbreviation: FDR, false discovery rate
  2. Genes that were differentially regulated by more than twofolds between U87-2M1 and U87 cells were screened using DAVID version 6.7, for enriched biological themes. Six most enriched gene ontology terms are listed
  3. bGenes that were differentially regulated by more than 1.5-fold after miR-10b silencing in U87-2M1 cells were screened with DAVID version 6.7, for identification of biological themes. Eight most enriched gene ontology terms are listed
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