Table 1 The modulatory effect of CM and mycelial fermentation on the cell cycle distribution of a non-apoptotic fraction of human glioblastoma GBM8401 cells and human glioblastoma U-87MG cells

From: Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells

 

Dose

GBM8401 cell cycle distribution

U-87MG cell cycle distribution

 

(mg/ml)

% G0/G1

% S

% G2/M

% G0/G1

% S

% G2/M

C. militaris

0

63.5±2.7

19.8±2.2

17.5±2.4

69.4±2.8

12.4±2.4

18.4±2.6

 

1

70.5±3.5*

24.7±2.3

5.2±2.7*

59.5±2.6*

14.6±2.4

26.2±3.3*

 

2

82.3±5.8*

16.1±2.3

1.8±2.2*

45.7±3.5*

9.8±3.6

45.3±4.3*

Mycelial

0

58.2±2.4

18.9±2.2

16.2±2.4

72.6±2.7

11.7±2.3

15.7±2.5

fermentation

1

61.9±2.3

17.0±2.3

16.8±2.6

69±2.4

15±3.1

24±2.7*

 

2

70.8±6.7*

21.3±3.3

8.5±2.3*

45.8±2.5*

9.8±2.9

45.4±3.7*

  1. Note: GBM8401 and U-87MG cells were treated with either CM or mycelial fermentation at the indicated dose for 24 h, followed by PI staining and subsequent flow cytometry. Data are shown as means±S.D. from three independent measurements.
  2. *P<0.05 using Student’s t-test compared with respective negative control